Agatha Raisin and the Potted Gardener (Agatha Raisin, Book by M. C. Beaton

By M. C. Beaton

Agatha is pissed off to discover appealing Mary Fortune ensconced within the affections of her fascinating bachelor neighbour. Mary is better in each means. So while she is came upon murdered, buried the other way up in a plant pot, Agatha seizes the instant and starts off yanking up village secrets and techniques and digging the airborne dirt and dust at the hapless sufferer. yet is that this clever? in the end, Agatha has an ungainly mystery too...

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Additional info for Agatha Raisin and the Potted Gardener (Agatha Raisin, Book 3)

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Antibodies against the protein of interest are applied to the membrane with the immobilized proteins. The binding of the specific antibodies to the protein is visualized with a second antibody targeted against the first antibody. , 1995; Couse and Korach, 1999). The direct comparison of the protein structure of ERa and ER~ reveals that the DNA-binding domains of both show an extremely high degree of homology; in fact, the protein structure differs only in three amino acids. On the other hand there is only a 59% homology in the ligand binding domain, which is of great importance for the ligand specificity and, therefore, also of great interest for pharmacological approaches and for the search for ER-subtype specific ligands (agonists and antagonists).

The so-called hinge-region or domain 0 separates the DNA binding domain (DBD) and the LBO and comprises a 40-50 amino acid long 37 "Estrogen's classics" - the genomic pathway of estrogen action c AlB D F E 595 hERa 530 h ER~ Transcriptional 3c:tivat ion AF-2 Af- I DNA binding oacli\'310r binding Corepressor binding Fig. 15. Structural and functional protein domains of ERa and IAdapted from Klinge, 2000) • • ER~ . peptide stretch responsible for the dimerization of the estrogen receptor and for the localization of the receptor dimer to the nucleus (NLS, nuclear localization sequences).

8). Obviously, the mechanism of this regularly occurring cycle is under a tight control of various endocrine feed back and feed forward loops. These interactions are complex enough and would need a much longer discussion for satisfactory understanding. Briefly, during the menstrual cycle estrogen induces massive physiological, morphological and structural changes of the uterus tissue, such as the proliferation of its mucosa. After ovulation, it is the progesterone that changes the physiology and pushes the endometrium into the phase of secretion.

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